Six other groups (recovery groups) received similar drug treatments but allowed to recover for 14 day before sacrificed. Control group received distilled water. ATS–Amod, ATS–SP and ATM–Lum, respectively, decreased ( p
Book Title: Study on Testicular Response to Prolong Artemisinin‐based Combination Therapy Treatments in Guinea Pigs
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Artemisinin‐based combination therapies (ACTs) are first‐line agents in malaria chemotherapy, but often abused in malaria endemic countries including Nigeria. This study investigated the effects of prolong treatment of artesunate–amodiaquine (ATS–Amod), artesunate‐sulfadoxine‐pyrimethamine (ATS–SP) and artemether–lumefantrine (ATM–Lum) on testicular indices in guinea pigs. Sixty‐five pigs were grouped into 13 ( n = 5 per group). Six groups were given standard or double therapeutic dose equivalents of ATS–Amod, ATS‐SP or ATM–Lum daily for 14 day and sacrificed 24 hr after treatments. Six other groups (recovery groups) received similar drug treatments but allowed to recover for 14 day before sacrificed. Control group received distilled water. ATS–Amod, ATS–SP and ATM–Lum, respectively, decreased ( p
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