Highlights: ADC values proved useful in the discrimination between TGCNs and normal testis. Testicular intraepithelial neoplasia represents the precursor of most TGCNs.
Book Title: The Role of Apparent Diffusion Coefficient Values in Detecting Testicular Intraepithelial Neoplasia: Preliminary Results
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Published on 2015 by
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Highlights: ADC values proved useful in the discrimination between TGCNs and normal testis. Testicular intraepithelial neoplasia represents the precursor of most TGCNs. ADC values cannot be used to detect testicular intraepithelial neoplasia. Abstract: Introduction: The aim of this study is to improve detection of testicular intraepithelial neoplasia (TIN) by measurement of apparent diffusion coefficient (ADC) values. Materials and methods: Fifty-six MRI examinations of the scrotum, including 26 histologically proven testicular germ cell neoplasms were retrospectively evaluated. DWI was performed using a single shot, multi-slice spin-echo planar diffusion pulse sequence and b -values of 0 and 900 s mm −2 . ADC measurements were classified into three groups according to their location: group 1 ( n = 19), non-tumoral part, adjacent to testicular carcinoma, where the possible location of TIN was; group 2 ( n = 26), testicular carcinoma; and group 3 ( n = 60), normal testicular parenchyma. Analysis of variance (ANOVA) followed by post hoc analysis (Dunnett T3) was used for statistical purposes. Results: The mean ± s.d. of ADC values (×10 −3 mm 2 /s) of different groups were: group 1, 1.08 ± 0.20; group 2, 0.72 ± 0.27; and group 3, 1.11 ± 0.14. ANOVA revealed differences of mean ADC between groups ( F = 38.859, P
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